Tian J[1][2], Huang YH[1][2], Wu T[1][2], Huang HD[2][3], Ko KM[4], Zhu BT[1][2], Chen J[1][2],
[1] Shenzhen Key Laboratory of Steroid Drug Discovery and Development, School of Life and Health Sciences, The Chinese University of Hong Kong, Shenzhen, China.
[2] School of Life and Health Sciences, The Chinese University of Hong Kong, Shenzhen, China.
[3] Warshel Institute for Computational Biology, The Chinese University of Hong Kong, Shenzhen, China.
[4] Division of Life Science, Hong Kong University of Science & Technology, Hong Kong, China.
Chronic kidney disease (CKD) is a leading cause of morbidity and mortality. Mitochondrial dysfunction has been implicated as a key factor in the development of CKD. According to traditional Chinese medicine (TCM) theory, many Chinese Yang/Qi-invigorating botanical drugs/herbal formulations have been shown to produce promising outcomes in the clinical management of CKD. Experimental studies have indicated that the health-promoting action of Yang/Qi invigoration in TCM is related to the up-regulation of mitochondrial energy generation and antioxidant status.