112. Long-term treatment with Shengmai San-derived herbal supplement (Wei Kang Su) enhances antioxidant response in various tissues of rats with protection against carbon tetrachloride hepatotoxicity.

Leong PK^[1], Chen N^[1], Chiu PY^[1], Leung HY^[1], Ma CW^[2], Tang QT^[2], Ko KM^[1]

[1] Department of Biochemistry, Hong Kong University of Science & Technology, Clear Water Bay, Hong Kong, China
[2] Lee Kum Kee Health Products Group Ltd., Hong Kong Special Administrative Region, China

Wei Kang Su (WKS) is a commercial herbal product based on a Chinese herbal formula, Shengmai San. Here, we investigated the effects of long-term treatment with WKS on mitochondrial antioxidant status and functional ability, as well as heat shock protein (Hsp) 25/70 production, in various tissues of rats. WKS treatment enhanced mitochondrial antioxidant status and ATP generation capacity, as well as Hsp 25/70 production in various rat tissues. WKS treatment suppressed plasma reactive oxygen metabolite levels and protected against carbon tetrachloride hepatotoxicity in rats. Long-term WKS treatment may prevent diseases by enhancing the resistance of mitochondria to oxidative stress.